Stimuli-responsive hydrogels for intratumoral drug delivery. Ana C Marques UCIBIO, REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Trans-mucosal delivery systems such as bio-adhesive gel strips with pathophysiological features for disease-responsive drug delivery and på sjukdomstillstånd-associerade stimuli ( t.ex. förhöjda glukoskoncentrationer i However, the MOF families and members, and the drug release mechanisms in MOF-based stimuli-responsive drug delivery systems (DDSs) are rarely summarized. Here, we systematically classified the families of MOF and introduced some representative members in MOF families. Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. Implementation of such devices requires the use of biocompatible materials that are susceptible to a specific physical incitement or that, in response to a specific stimulus, undergo a protonation, a hydrolytic cleavage or a (supra)molecular conformational change.

Department of Anatomy, Physiology and Pharmacology, Bogor University of Calcutta - ‪‪Citerat av 216‬‬ - ‪Nanomaterials‬ - ‪Drug delivery‬ MOF Entrapping Hydrophobic Photosensitizer for Dual- Stimuli-Responsive av C De la Torre Paredes · 2018 — Control release of cargo. 66. 1.3.4.1 Endogenous stimule responsive drug delivery materials. 68. 1.3.4.2 Exogenous stimuli responsive drug delivery materials. Ellibs E-bokhandel - E-bok: Responsive Membranes and Materials new multifunctional membranes and materials which respond to external stimuli, such as which range from biopharmaceutical, to drug delivery systems to water treatment.

211 Stimuli Responsive Drug Delivery Systems: From Introduction to Application 212 Related Papers. Electrical response characterisation of poly (ethylene glycol) macromer (PEGM)/chitosan hydrogels in NaCl solution. By Siridech Boonsang. Polyelectrolyte Intelligent Gels: …

2020-02-01 · MOF-based stimuli-responsive drug delivery Due to the introduction of stimuli responsive groups or materials into MOF structure, such as imidazolyl (pH), disulfide bond (GSH), porphyrin (light) and etc., the smart materials will undergo molecular conformational changes, protonation or hydrolytic cleavage under stimuli, leading to the release of guest molecules [ 107 ]. Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities.

Feb 25, 2021 Stimuli-responsive drug-delivery systems have emerged as potential tools for advanced treatment of cancers. Versatile nano-carriers

Versatile nano-carriers co-triggered by multiple stimuli in different levels of organisms (eg, extracorporeal, tumor tissue, cell, subcellular organelles) In this work, we report a smart stimuli-responsive drug delivery system (DDS) that can release drug depending upon the amount of pathogen (MRSA) present in the target.

Adv Drug Deliv Rev. 2013 Nov;65(13-14):1699-715. doi: 10.1016/j.addr.2013.04.011. Epub 2013 Apr 20. Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor. 2. Stimuli-Responsive Drug Delivery Systems Stimuli-based drug delivery systems have constituted a new platform in the under-standing of diseases at the molecular level. For this purpose, nanotechnology-based drug delivery systems offer tremendous and promising advantages in the prevention, diagnosis Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible.
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The partnership between suitable solid support-based drug nanocarriers and supramolecular nanovalves led to a variety of gated materials containing supramolecular switches and polymers that are capable of targeted delivery and on-demand release of drugs Purchase Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications - 1st Edition. Print Book & E-Book. ISBN 9780081019955, 9780081019962 delivery systems activated by external remote triggers are also discussed.

Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. Implementation of such devices requires the use of biocompatible materials that are susceptible to a … Moreover, the single stimulus-responsive prodrugs, dual stimuli-responsive prodrugs and even triple stimuli-responsive prodrugs associated with the cancer cell microenvironment through active targeting, passive targeting or dual active and passive targeting for chemotherapy, gene therapy and theranostic applications could be achieved through a prodrug-based drug delivery strategy .
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molecular polymers and supramolecular pseudorotaxanes for stimuli-responsive drug delivery, which not only endow the delivery systems with ﬂexible and robust attributes of non-covalent interactions but also meet the urgent need of human healthcare.18–20 Drug-delivery systems immobilized with supramolecular nanovalves, emerging as a

pH-responsive systems take advantage of the significant variations in pH to stimulate localized drug delivery to different regions of the body such as the gastrointestinal tract, tumor microenvironment, or to the endosomal/lysosomal compartments of the cell (Figure 1). Stimuli-responsive drug-delivery nanocarriers (DDNs) have been increasingly reported in the literature as an alternative for breast cancer therapy. Stimuli-responsive DDNs are developed with materials that present a drastic change in response to intrinsic/chemical stimuli (pH, redox and enzyme) and extrinsic/physical stimuli (ultrasound, Near-infrared (NIR) light, magnetic field and electric current). A crucial strategy involves drug‐carrier linkages able to respond to physiological or biochemical stimuli present in the disease region, and there is now significant literature on (polymeric) prodrugs based on the drug + carrier + cleavable linker philosophy, predominantly for cancer applications.

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stimuli responsive polymer integrated targeted nanomedicine is designed for combined cancer-targeted therapy and multimodal imaging using a facile preparation method. The nanoprobes used were found to offer dual pH and temperature responsive drug delivery capability, and are specifically targeted to cancer cells which also shows intracellular MR based diagnostic and tracking ability.

Stimuli-Responsive Drug Delivery Systems Stimuli-based drug delivery systems have constituted a new platform in the under-standing of diseases at the molecular level. For this purpose, nanotechnology-based drug delivery systems offer tremendous and promising advantages in the prevention, diagnosis 2019-06-14 c) Thermoresponsive drug delivery system: The use of temperature as a signal has been justified by the fact that the body temperature often deviates from the physiological temperature (37°C) in the presence of pathogens or pyrogens. This deviation is a useful stimulus that activates the release of therapeutic agents from various temperature-responsive drug delivery systems for diseases delivery systems activated by external remote triggers are also discussed.